GPSM1 impairs metabolic homeostasis by controlling a pro-inf (2024)

Author

Listed:

  • Jing Yan

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Yuemei Zhang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Hairong Yu

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Yicen Zong

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Daixi Wang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Jiangfei Zheng

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Li Jin

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Xiangtian Yu

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Caizhi Liu

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Yi Zhang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Feng Jiang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Rong Zhang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Xiangnan Fang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Ting Xu

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Mingyu Li

    (Shanghai Jiao Tong University School of Medicine)

  • Jianzhong Di

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Yan Lu

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Xinran Ma

    (East China Normal University)

  • Jian Zhang

    (Shanghai Jiao Tong University School of Medicine
    Zhengzhou University)

  • Weiping Jia

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Cheng Hu

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Fengxian Central Hospital Affiliated to Southern Medical University)

Registered:

    Abstract

    G-protein-signaling modulator 1 (GPSM1) exhibits strong genetic association with Type 2 diabetes (T2D) and Body Mass Index in population studies. However, how GPSM1 carries out such control and in which types of cells are poorly understood. Here, we demonstrate that myeloid GPSM1 promotes metabolic inflammation to accelerate T2D and obesity development. Mice with myeloid-specific GPSM1 ablation are protected against high fat diet-induced insulin resistance, glucose dysregulation, and liver steatosis via repression of adipose tissue pro-inflammatory states. Mechanistically, GPSM1 deficiency mainly promotes TNFAIP3 transcription via the Gαi3/cAMP/PKA/CREB axis, thus inhibiting TLR4-induced NF-κB signaling in macrophages. In addition, we identify a small-molecule compound, AN-465/42243987, which suppresses the pro-inflammatory phenotype by inhibiting GPSM1 function, which could make it a candidate for metabolic therapy. Furthermore, GPSM1 expression is upregulated in visceral fat of individuals with obesity and is correlated with clinical metabolic traits. Overall, our findings identify macrophage GPSM1 as a link between metabolic inflammation and systemic homeostasis.

    Suggested Citation

  • Jing Yan & Yuemei Zhang & Hairong Yu & Yicen Zong & Daixi Wang & Jiangfei Zheng & Li Jin & Xiangtian Yu & Caizhi Liu & Yi Zhang & Feng Jiang & Rong Zhang & Xiangnan Fang & Ting Xu & Mingyu Li & Jianzh, 2022."GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages,"Nature Communications, Nature, vol. 13(1), pages 1-22, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34998-9
    DOI: 10.1038/s41467-022-34998-9

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    References listed on IDEAS

    1. Kathryn Tunyasuvunakool & Jonas Adler & Zachary Wu & Tim Green & Michal Zielinski & Augustin Žídek & Alex Bridgland & Andrew Cowie & Clemens Meyer & Agata Laydon & Sameer Velankar & Gerard J. Kleywegt, 2021."Highly accurate protein structure prediction for the human proteome,"Nature, Nature, vol. 596(7873), pages 590-596, August.
    2. Mengle Shao & Bo Shan & Yang Liu & Yiping Deng & Cheng Yan & Ying Wu & Ting Mao & Yifu Qiu & Yubo Zhou & Shan Jiang & Weiping Jia & Jingya Li & Jia Li & Liangyou Rui & Liu Yang & Yong Liu, 2014."Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling,"Nature Communications, Nature, vol. 5(1), pages 1-12, May.
    3. John Jumper & Richard Evans & Alexander Pritzel & Tim Green & Michael Figurnov & Olaf Ronneberger & Kathryn Tunyasuvunakool & Russ Bates & Augustin Žídek & Anna Potapenko & Alex Bridgland & Clemens Me, 2021."Highly accurate protein structure prediction with AlphaFold,"Nature, Nature, vol. 596(7873), pages 583-589, August.
    4. Mengle Shao & Lavanya Vishvanath & Napoleon C. Busbuso & Chelsea Hepler & Bo Shan & Ankit X. Sharma & Shiuhwei Chen & Xinxin Yu & Yu A. An & Yi Zhu & William L. Holland & Rana K. Gupta, 2018."De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity,"Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    5. Jason Flannick & Josep M. Mercader & Christian Fuchsberger & Miriam S. Udler & Anubha Mahajan & Jennifer Wessel & Tanya M. Teslovich & Lizz Caulkins & Ryan Koesterer & Francisco Barajas-Olmos & Thomas, 2019."Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls,"Nature, Nature, vol. 570(7759), pages 71-76, June.
    6. Ozlem Senol-Cosar & Rachel J. Roth Flach & Marina DiStefano & Anil Chawla & Sarah Nicoloro & Juerg Straubhaar & Olga T. Hardy & Hye Lim Noh & Jason K. Kim & Martin Wabitsch & Philipp E. Scherer & Mich, 2016."Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion,"Nature Communications, Nature, vol. 7(1), pages 1-13, April.
    7. Miyako Tanaka & Kenji Ikeda & Takayoshi Suganami & Chikara Komiya & Kozue Ochi & Ibuki Shirakawa & Miho Hamaguchi & Satoshi Nishimura & Ichiro Manabe & Takahisa Matsuda & Kumi Kimura & Hiroshi Inoue &, 2014."Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis,"Nature Communications, Nature, vol. 5(1), pages 1-13, December.
    8. Khoa D. Nguyen & Yifu Qiu & Xiaojin Cui & Y. P. Sharon Goh & Julia Mwangi & Tovo David & Lata Mukundan & Frank Brombacher & Richard M. Locksley & Ajay Chawla, 2011."Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis,"Nature, Nature, vol. 480(7375), pages 104-108, December.

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    GPSM1 impairs metabolic homeostasis by controlling a pro-inf (2024)

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